Blueberries studied as natural arthritis treatment by Oklahoma researchers

Could something as simple as a handful of blueberries help ease arthritis pain? Scientists at the Oklahoma Medical Research Foundation (OMRF) are launching a clinical trial to find out.

Blueberries, rich in antioxidants, are being put to the test to see if they can reduce inflammation and discomfort for people with two of the most common types of arthritis. The study follows earlier research suggesting berries may benefit joint health — and possibly more.

What the study is testing

The new clinical trial will focus on 80 volunteers split evenly between those with osteoarthritis and those with rheumatoid arthritis. Over the next six months:

1. Half of the participants will receive a daily powder equal to one cup of blueberries
2. The other half will receive a placebo

Researchers will track whether the berry-based supplement leads to improvements in joint pain, stiffness, and daily function.

Why blueberries?

A 2019 study found that people with knee osteoarthritis who consumed around 1½ ounces of freeze-dried blueberry powder daily experienced measurable relief from pain and stiffness.

Dr. Matlock Jeffries, one of the lead researchers on the new OMRF study, says blueberries may reduce inflammation by altering gut bacteria — increasing the “good” and reducing the “bad.”

Backed by berry supporters

The study is being funded by the Wild Blueberry Association of North America, which promotes awareness of the fruit’s health benefits.

Jeffries is joined by co-lead researcher Dr. Hal Scofield, who has studied the effects of strawberries on osteoarthritis. His previous work suggested berries may not only help with joint pain, but also reduce the risk of heart disease, stroke, and diabetes.

“We’ve long known that berries reduce inflammation and are good for your heart,” said Scofield, who also serves as assistant chief of staff for research at the Oklahoma City VA Medical Center. “This study promises to expand what we know about the connection between arthritis and our diet.”

Osteoarthritis by the numbers

Osteoarthritis affects about 32.5 million Americans, according to the Centers for Disease Control and Prevention. The World Health Organization warns that the number is climbing as populations age and physical activity decreases.

Researchers hope the trial will help explain how food-based solutions might offer relief — potentially without the side effects of medication.

What’s next?

The OMRF team will continue recruiting volunteers and conducting tests through the fall. Results from the study could be available in early 2026.

For more information, visit OMRF.org.